Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased Tumor Necrosis Factor (TNF)-α and its promoter polymorphisms correlate with disease progression and higher susceptibility towards vitiligo.

PloS one - 20 Dec 2012

Laddha Naresh C, Dwivedi Mitesh, Begum Rasheedunnisa

Abstract excerpt

Tumor Necrosis Factor (TNF)-α, is a paracrine inhibitor of melanocytes, which plays a critical role in the pathogenesis of several autoimmune diseases including vitiligo, as abnormal immune responses have frequently been observed in vitiligo patients. Moreover, vitiligo patients show higher lesion levels of TNF-α. Genetic polymorphisms in the promoter region of TNF-α are involved in the regulation of its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Disease Progression
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Haplotypes

Share to Promoter Regions, Genetic

Share to Tumor Necrosis Factor-alpha

Share to Vitiligo

Source

Open in PubMed Open full text

Identifiers

PMID: 23284977
DOI: 10.1371/journal.pone.0052298
PMCID: PMC3527546

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased Tumor Necrosis Factor (TNF)-α and its promoter polymorphisms correlate with disease progression and higher susceptibility towards vitiligo.PMID 23284977Read ↗

Tumor necrosis factor-α and -β genetic polymorphisms as a risk factor in Saudi patients with vitiligo.Semantic proximity Read ↗

Association Analysis of Tumor Necrosis Factor Alpha Promoter Polymorphisms and Vitiligo Susceptibility in South Indian Tamils.Semantic proximity Read ↗

Meta-analysis for association of TNFA-308(G > A) SNP with vitiligo susceptibility.Semantic proximity Read ↗

Tumor necrosis factor (TNF)-α- 308 G/A gene polymorphism (rs1800629) in Egyptian patients with alopecia areata and vitiligo, a laboratory and in silico analysis.Semantic proximity Read ↗

Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk.Semantic proximity Read ↗

The association between tumor necrosis factor-α-308 G/A polymorphism and risk for vitiligo: a meta-analysis.Semantic proximity Read ↗

The combination of tumour necrosis factor-α -308A and interleukin-10 -1082G gene polymorphisms and increased serum levels of related cytokines: susceptibility to vitiligo.Semantic proximity Read ↗

Association of interferon-gamma and tumor necrosis factor alpha polymorphisms with susceptibility to vitiligo in Iranian patients.Semantic proximity Read ↗

Identification of TNF-α as Major Susceptible Risk Locus for Vitiligo: A Systematic Review and Meta-Analysis Study in the Asian Population.Semantic proximity Read ↗

Tumor necrosis factor B (TNFB) genetic variants and its increased expression are associated with vitiligo susceptibility.Semantic proximity Read ↗

Liver X Receptor-α polymorphisms (rs11039155 and rs2279238) are associated with susceptibility to vitiligoSemantic proximity Read ↗

Lack of association with TNF-alpha-308 promoter polymorphism in patients with vitiligo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.