Impact of cytotoxic T-lymphocyte-associated protein 4 codon 17 variant and expression on vitiligo risk.

doi:10.1002/jcla.23777

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Article

Impact of cytotoxic T-lymphocyte-associated protein 4 codon 17 variant and expression on vitiligo risk.

Journal of clinical laboratory analysis - 1 Jun 2021

Gouda Nawal S, Fawzy Manal S, Toraih Eman A

Abstract excerpt

BACKGROUND: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is one of the essential brakes expressed on T cells that prevent T-cell hyperactivation-associated autoimmune disorders. Several CTLA4 polymorphisms were implicated in the regulation of gene expression. We aimed to explore the association of CTLA4 expression and rs231775 (c.49A>G) variant with vitiligo risk and severity of the disease in a sample of...

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PMID: 33932254
DOI: 10.1002/jcla.23777
PMCID: PMC8183918

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