Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary analysis of the most polymorphic gene family in falciparum malaria

3 Dec 2019

Abstract excerpt

The var gene family of the human malaria parasite Plasmodium falciparum encode proteins that are crucial determinants of both pathogenesis and immune evasion and are highly polymorphic. Here we have assembled nearly complete var gene repertoires from 2398 field isolates and analysed a normalised set of 714 from across 12 countries. This therefore represents the first large scale attempt to catalogue the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Invertebrate Immune Response Mechanisms
Share to Malaria Research and Control
Share to Parasites and Host Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32055709
DOI: 10.12688/wellcomeopenres.15590.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary analysis of the most polymorphic gene family in falciparum malariaPMID 32055709Read ↗

Var gene diversity in Plasmodium falciparum is generated by frequent recombination events.Semantic proximity Read ↗

A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa.Semantic proximity Read ↗

Evidence for the importance of genetic structuring to the structural and functional specialization of the <i>Plasmodium falciparum var</i> gene familySemantic proximity Read ↗

A sub-family of common and highly conserved Plasmodium falciparum var genesSemantic proximity Read ↗

Population genomics of the immune evasion (var) genes of Plasmodium falciparum.Semantic proximity Read ↗

A paradoxical population structure of <i>var</i> DBLα types in AfricaSemantic proximity Read ↗

Phylogeography of var gene repertoires reveals fine-scale geospatial clustering of Plasmodium falciparum populations in a highly endemic area.Semantic proximity Read ↗

Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria.Semantic proximity Read ↗

The South American Plasmodium falciparum var gene repertoire is limited, highly shared and possibly lacks several antigenic types.Semantic proximity Read ↗

Evolution of the multi-domain structures of virulence genes in the human malaria parasite, Plasmodium falciparum.Semantic proximity Read ↗

Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates.Semantic proximity Read ↗

Genetic diversity of Plasmodium falciparum erythrocyte membrane protein 1 in field isolates from central Myanmar.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.