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Article

PPARA: a novel genetic determinant of CYP3A4 in vitro and in vivo.

Clinical pharmacology and therapeutics - 1 Jun 2012

Klein Kathrin, Thomas Maria, Winter Stefan, Nussler Andreas K, Niemi Mikko, Schwab Matthias, Zanger Ulrich M

Abstract excerpt

Interindividual variability in cytochrome P450 3A4 (CYP3A4) is believed to be largely heritable; however, predictive genetic factors have remained scarce. Using a candidate-gene approach in a human liver bank, we identified single-nucleotide polymorphisms (SNPs) in the Ah-receptor nuclear translocator (ARNT), glucocorticoid receptor (GR), progesterone receptor membrane component 2 (PGRMC2), and peroxisome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22510778
DOI: 10.1038/clpt.2011.336

Genes

PPARA
ACOX1
ARNT
PGRMC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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