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Article

Leveraging drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans.

American journal of human genetics - 5 Jan 2023

Zhong Yizhen, De Tanima, Mishra Mrinal, Avitia Juan, Alarcon Cristina, Perera Minoli A

Abstract excerpt

Expression quantitative locus (eQTL) studies have paved the way in identifying genetic variation impacting gene expression levels. African Americans (AAs) are disproportionately underrepresented in eQTL studies, resulting in a lack of power to identify population-specific regulatory variants especially related to drug response. Specific drugs are known to affect the biosynthesis of drug metabolism enzymes as well...

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Identifiers

PMID: 36608685
DOI: 10.1016/j.ajhg.2022.12.005
PMCID: PMC9892765

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