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Polymorphism in Cytochrome P450 3A4 Is Ethnicity Related

19 Mar 2019

Abstract excerpt

Can mutations in Cytochrome P450 3A4 (CYP3A4), the major food- and drug-metabolizing enzyme, serve as biomarkers for personalized precise medicine? Classical genetic studies provide only limited data regarding the frequencies of CYP3A4 mutations and their role in food-drug interactions. Here, in an analysis of one large database of 141,456 individuals, we found 856 SNPs (single nucleotide polymorphism), of which...

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PMID: 30941162
DOI: 10.3389/fgene.2019.00224

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