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Article

Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.

Pharmacogenomics - 1 Aug 2013

de Keyser Catherine E, Becker Matthijs L, Uitterlinden André G, Hofman Albert, Lous Jan J, Elens Laure, Visser Loes E, van Schaik Ron Hn, Stricker Bruno H

Abstract excerpt

AIM: Recently, minor alleles of two strongly linked polymorphisms in the PPARA gene, rs4253728 G>A and rs4823613 A>G, were related to decreased CYP3A4 expression and activity. We studied whether they were associated with the cholesterol-lowering effect of simvastatin. MATERIALS & METHODS: We identified 123 incident users with cholesterol measurements before and after starting statin therapy in a prospective...

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Identifiers

PMID: 23930676
DOI: 10.2217/pgs.13.112

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PPARA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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