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Article

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

26 Aug 2009

Abstract excerpt

BACKGROUND: Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver. Here we set out to compare the function of PPARalpha in mouse and human hepatocytes via analysis of target gene regulation. METHODOLOGY/PRINCIPAL FINDINGS: Primary hepatocytes from 6 human and 6...

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PMID: 19710929
DOI: 10.1371/journal.pone.0006796

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