Article
Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors.
The pharmacogenomics journal - 1 Aug 2016
Emami Riedmaier A, Burk O, van Eijck B A C, Schaeffeler E, Klein K, Fehr S, Biskup S, Müller S, Winter S, Zanger U M, Schwab M, Nies A T
Abstract excerpt
Human organic anion transporter 7 (OAT7, SLC22A9) is a hepatic transport protein poorly characterized so far. We therefore sought to identify novel OAT7 substrates and factors contributing to variable hepatic OAT7 expression. Using OAT7-expressing cells, pravastatin was identified as a substrate....
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