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Article

Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression.

Molecular psychiatry - 1 Feb 2013

Bangasser D A, Reyes B A S, Piel D, Garachh V, Zhang X-Y, Plona Z M, Van Bockstaele E J, Beck S G, Valentino R J

Abstract excerpt

Stress-related psychiatric disorders are more prevalent in women than men. As hypersecretion of the stress neuromediator, corticotropin-releasing factor (CRF) has been implicated in these disorders, sex differences in CRF sensitivity could underlie this disparity. Hyperarousal is a core symptom that is shared by stress-related disorders and this has been attributed to CRF regulation of the locus ceruleus...

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PMID: 22508464
DOI: 10.1038/mp.2012.24
PMCID: PMC3402704

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