Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice.

Nature communications - 23 Aug 2021

Levine Olivia B, Skelly Mary Jane, Miller John D, Rivera-Irizarry Jean K, Rowson Sydney A, DiBerto Jeffrey F, Rinker Jennifer A, Thiele Todd E, Kash Thomas L, Pleil Kristen E

Abstract excerpt

Bed nucleus of the stria terminalis (BNST) neurons that synthesize corticotropin-releasing factor (CRF) drive binge alcohol drinking and anxiety. Here, we found that female C57BL/6J mice binge drink more than males and have greater basal BNSTCRF neuron excitability and synaptic excitation. We identified a dense VGLUT2 + synaptic input from the paraventricular thalamus (PVT) that releases glutamate directly onto...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Avoidance Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corticotropin-Releasing Hormone

Share to Excitatory Postsynaptic Potentials

Share to Integrases

Share to Limbic System

Share to Synapses

Share to Thalamus

Source

Open in PubMed Open full text

Identifiers

PMID: 34426574
DOI: 10.1038/s41467-021-25368-y
PMCID: PMC8382748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice.PMID 34426574Read ↗

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behaviorSemantic proximity Read ↗

Distinct extended amygdala circuits for divergent motivational states.Semantic proximity Read ↗

An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes.Semantic proximity Read ↗

Contrasting adaptations to synaptic physiology of prefrontal cortex interneuron subtypes in a mouse model of binge drinkingSemantic proximity Read ↗

Chronic variable mild stress alters the transcriptome and signaling properties of the anterodorsal bed nuceleus of the stria terminalis in a sex-dependent mannerSemantic proximity Read ↗

TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuitsSemantic proximity Read ↗

Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse ModelSemantic proximity Read ↗

Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice.Semantic proximity Read ↗

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors.Semantic proximity Read ↗

Nutritional Ketosis Attenuates Sucrose Bingeing-Induced Behavioral Deficits by Improving Synaptic Plasticity and Anti-Inflammatory Signalling in the Prefrontal CortexSemantic proximity Read ↗

A subset of dorsal raphe dopamine neurons is critical for survival-oriented vigilanceSemantic proximity Read ↗

Characterizing the phenotype of pre-Bötzinger Complex neurons in rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.