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Article

Combinatorics of the breakage-fusion-bridge mechanism.

Journal of computational biology : a journal of computational molecular cell biology - 1 Jun 2012

Kinsella Marcus, Bafna Vineet

Abstract excerpt

The breakage-fusion-bridge (BFB) mechanism was proposed over seven decades ago and is a source of genomic variability and gene amplification in cancer. Here we formally model and analyze the BFB mechanism, to our knowledge the first time this has been undertaken. We show that BFB can be modeled a...

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Identifiers

PMID: 22506505
DOI: 10.1089/cmb.2012.0020
PMCID: PMC3375649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22506505-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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