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Article

Are there rearrangement hotspots in the human genome?

PLoS computational biology - 1 Nov 2007

Alekseyev Max A, Pevzner Pavel A

Abstract excerpt

In a landmark paper, Nadeau and Taylor [18] formulated the random breakage model (RBM) of chromosome evolution that postulates that there are no rearrangement hotspots in the human genome. In the next two decades, numerous studies with progressively increasing levels of resolution made RBM the de facto theory of chromosome evolution. Despite the fact that RBM had prophetic prediction power, it was recently...

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Identifiers

PMID: 17997591
DOI: 10.1371/journal.pcbi.0030209
PMCID: PMC2065889

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