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Article

The Functions of Mediator in Candida albicans Support a Role in Shaping Species-Specific Gene Expression

5 Apr 2012

Abstract excerpt

The Mediator complex is an essential co-regulator of RNA polymerase II that is conserved throughout eukaryotes. Here we present the first study of Mediator in the pathogenic fungus Candida albicans. We focused on the Middle domain subunit Med31, the Head domain subunit Med20, and Srb9/Med13 from the Kinase domain. The C. albicans Mediator shares some roles with model yeasts Saccharomyces cerevisiae and...

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PMID: 22496666
DOI: 10.1371/journal.pgen.1002613

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