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Article

Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits.

PLoS genetics - 1 Oct 2014

Haran John, Boyle Hannah, Hokamp Karsten, Yeomans Tim, Liu Zhongle, Church Michael, Fleming Alastair B, Anderson Matthew Z, Berman Judith, Myers Lawrence C, Sullivan Derek J, Moran Gary P

Abstract excerpt

The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator complex with homology to Med2. The more virulent pathogen C. albicans has 15 copies of the gene whereas the less pathogenic species C. dublinie...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25356803
DOI: 10.1371/journal.pgen.1004658
PMCID: PMC4214616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25356803-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits.PMID 25356803Read ↗

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