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Article

Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.

Molecular biology of the cell - 1 Jun 2012

Mohan Swarna, Rizaldy Ryan, Das Debamitra, Bauer Robert J, Heroux Annie, Trakselis Michael A, Hildebrand Jeffrey D, VanDemark Andrew P

Abstract excerpt

Shroom (Shrm) proteins are essential regulators of cell shape and tissue morpho-logy during animal development that function by interacting directly with the coiled-coil region of Rho kinase (Rock). The Shrm-Rock interaction is sufficient to direct Rock subcellular localization and the subsequent...

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Identifiers

PMID: 22493320
DOI: 10.1091/mbc.E11-11-0937
PMCID: PMC3364177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22493320-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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