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Article

Structure of MST2 SARAH domain provides insights into its interaction with RAPL.

Journal of structural biology - 1 Mar 2014

Liu Guoguang, Shi Zhubing, Jiao Shi, Zhang Zhenzhen, Wang Wenjia, Chen Cuicui, Hao Qian, Hao Qiao, Zhang Meng, Feng Miao, Xu Liang, Zhang Zhen, Zhou Zhaocai, Zhang Min

Abstract excerpt

The STE20 kinases MST1 and MST2 are key players in mammalian Hippo pathway. The SARAH domains of MST1/2 act as a platform to mediate homodimerization and hetero-interaction with a range of adaptors including RASSFs and Salvador, which also possess SARAH domains. Here, we determined the crystal structure of human MST2 SARAH domain, which forms an antiparallel homodimeric coiled coil. Structural comparison...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24468289
DOI: 10.1016/j.jsb.2014.01.008

Genes

MST1
RASSF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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