Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Background Modulates Zoliflodacin and Gepotidacin Cross-Resistance and Fitness in Neisseria gonorrhoeae.

The Journal of infectious diseases - 3 Aug 2026

Mukherjee Aditi, Blomqvist Sofia O P, Helekal David, Das Apabrita A, Palace Samantha G, Grad Yonatan H

Abstract excerpt

BACKGROUND: The emergence of multidrug-resistant Neisseria gonorrhoeae has created an urgent need for new therapeutic options. Zoliflodacin and gepotidacin, 2 first-in-class topoisomerase inhibitors, are oral antibiotics recently approved by the FDA for gonorrhea treatment. Resistance to zoliflodacin can occur through gyrBD429N, but this mutation's impact on fitness and on resistance to other...

Topics

Join the communities discussing this publication.

Ciprofloxacin
Gonorrhea
Heterocyclic Compounds, 3-Ring
Isoxazoles
Morpholines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neisseria gonorrhoeae

Spiro Compounds

Source

Open in PubMed Open full text

Identifiers

PMID: 41858024
DOI: 10.1093/infdis/jiag174
PMCID: PMC13061509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Background Modulates Zoliflodacin and Gepotidacin Cross-Resistance and Fitness in Neisseria gonorrhoeae.PMID 41858024Read ↗

Zoliflodacin and gepotidacin cross-resistance in <i>Neisseria gonorrhoeae</i>Semantic proximity Read ↗

Stepwise evolution and clonal enrichment of gepotidacin resistance in Neisseria gonorrhoeae.Semantic proximity Read ↗

Gonococcal resistance to zoliflodacin could emerge via transformation from commensal Neisseria species. An in-vitro transformation studySemantic proximity Read ↗

Using a public database of Neisseria gonorrhoeae genomes to detect mutations associated with zoliflodacin resistance.Semantic proximity Read ↗

Impact of fluoroquinolone resistance mutations on gonococcal fitness and in vivo selection for compensatory mutations.Semantic proximity Read ↗

Neisseria gonorrhoeae diagnostic escape from a gyrA-based test for ciprofloxacin susceptibility and the effect on zoliflodacin resistance: a bacterial genetics and experimental evolution studySemantic proximity Read ↗

<i>In vitro</i> evolution of ciprofloxacin resistance in <i>Neisseria</i> commensals and derived mutation population dynamics in natural <i>Neisseria</i> populationsSemantic proximity Read ↗

Determination of frequency of spontaneous resistance for gepotidacin and levofloxacin against a collection of gram-positive and gram-negative organisms.Semantic proximity Read ↗

GyrB in silico mining in 27 151 global gonococcal genomes from 1928-2021 combined with zoliflodacin in vitro testing of 71 international gonococcal isolates with different GyrB, ParC and ParE substitutions confirms high susceptibility.Semantic proximity Read ↗

In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae.Semantic proximity Read ↗

Genetic Resistance Determinants, In Vitro Time-Kill Curve Analysis and Pharmacodynamic Functions for the Novel Topoisomerase II Inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeaeSemantic proximity Read ↗

Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.