Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of quinolone resistance mechanisms in Neisseria gonorrhoeae isolates in vitro.

Sexually transmitted infections - 1 Feb 1998

Tanaka M, Sakuma S, Takahashi K, Nagahuzi T, Saika T, Kobayashi I, Kumazawa J

Abstract excerpt

BACKGROUND AND OBJECTIVES: Gonococcal fluoroquinolone resistance is now a significant problem in Japan. We generated gonococcal mutants resistant to norfloxacin in vitro from norfloxacin sensitive isolates and analysed the contribution of three known mechanisms of quinolone resistance in Neisseri...

Topics

Anti-Infective Agents
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Genes, Bacterial
Humans
Male
Microbial Sensitivity Tests
Mutation
Neisseria gonorrhoeae
Norfloxacin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 9634306
DOI: 10.1136/sti.74.1.59
PMCID: PMC1758082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9634306-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of quinolone resistance mechanisms in Neisseria gonorrhoeae isolates in vitro.PMID 9634306Read ↗

Analysis of quinolone resistance mechanisms in a sparfloxacin-resistant clinical isolate of Neisseria gonorrhoeae.Semantic proximity Read ↗

Development of fluoroquinolone resistance and mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae isolates in Japan.Semantic proximity Read ↗

In vitro selection of fluoroquinolone-resistant Neisseria gonorrhoeae harboring alterations in DNA gyrase and topoisomerase IV.Semantic proximity Read ↗

Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 91 clinical isolates of Neisseria gonorrhoeae in Japan.Semantic proximity Read ↗

Fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Russia: molecular mechanisms implicated.Semantic proximity Read ↗

Fluoroquinolone resistance among Neisseria gonorrhoeae isolates from Shanghai, China: detection of quinolone resistance-determining region mutations.Semantic proximity Read ↗

High occurrence of simultaneous mutations in target enzymes and MtrRCDE efflux system in quinolone-resistant Neisseria gonorrhoeae.Semantic proximity Read ↗

Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype.Semantic proximity Read ↗

Fluoroquinolone resistance and mutation patterns in gyrA and parC genes in Neisseria gonorrhoeae isolates from Shanghai, China.Semantic proximity Read ↗

[Study on fluoroquinolone resistance and the relationship between resistance and mutations of gyrA and parC in Neisseria gonorrhoeae].Semantic proximity Read ↗

In vitro assessment of the further potential for development of fluoroquinolone resistance in Neisseria meningitidis.Semantic proximity Read ↗

Antimicrobial susceptibility and molecular determinants of quinolone resistance in Neisseria gonorrhoeae isolates from Shanghai.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.