Article
In vitro selection of fluoroquinolone-resistant Neisseria gonorrhoeae harboring alterations in DNA gyrase and topoisomerase IV.
The Journal of urology - 1 Sept 2000
Yasuda M, Fukuda H, Yokoi S, Ishihara S, Kawada Y, Deguchi T
Abstract excerpt
PURPOSE: We attempted to select increasingly fluoroquinolone-resistant strains of Neisseria gonorrhoeae in vitro and to assess whether selected mutants harbored alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV, which were analogous to those in fluoroquino...
Topics
- Anti-Infective Agents
- Aspartic Acid
- Ciprofloxacin
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Escherichia coli
- Genes, Bacterial
- Glutamic Acid
- Humans
- Microbial Sensitivity Tests
- Mutation
- Neisseria gonorrhoeae
- Norfloxacin
- Ofloxacin
- Selection, Genetic