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Article

Evolution of isotype switching.

Seminars in immunology - 1 Aug 2004

Stavnezer Janet, Amemiya Chris T

Abstract excerpt

This review discusses evolution of the process of Ig heavy chain class switching, relating it to the first appearance of somatic hypermutation (SHM) of variable region genes. First, we discuss recent findings on the mechanism of class switch recombination (CSR) in mice and humans, and then review the mechanisms of expression of Ig heavy chain isotypes from fishes to mammals. Importantly, activation-induced...

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Source

Identifiers

PMID: 15522624
DOI: 10.1016/j.smim.2004.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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