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Article

Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b.

Journal of neurophysiology - 1 Jul 2012

Low Sean E, Woods Ian G, Lachance Mathieu, Ryan Joel, Schier Alexander F, Saint-Amant Louis

Abstract excerpt

The molecular and physiological basis of the touch-unresponsive zebrafish mutant fakir has remained elusive. Here we report that the fakir phenotype is caused by a missense mutation in the gene encoding voltage-gated calcium channel 2.1b (CACNA1Ab). Injection of RNA encoding wild-type CaV2.1 restores touch responsiveness in fakir mutants, whereas knockdown of CACNA1Ab via morpholino oligonucleotides recapitulates...

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Identifiers

PMID: 22490555
DOI: 10.1152/jn.00839.2011
PMCID: PMC3434603

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