Article
The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation.
The European journal of neuroscience - 1 Jun 2006
Macleod G T, Chen L, Karunanithi S, Peloquin J B, Atwood H L, McRory J E, Zamponi G W, Charlton M P
Abstract excerpt
Voltage-gated Ca2+ channels in nerve terminals open in response to action potentials and admit Ca2+, the trigger for neurotransmitter release. The cacophony gene encodes the primary presynaptic voltage-gated Ca2+ channel in Drosophila motor-nerve terminals. The cac(ts2) mutant allele of cacophony is associated with paralysis and reduced neurotransmission at non-permissive temperatures but the basis for the...
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