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Article

Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene.

Molecular neurobiology - 1 Apr 2020

Gawel Kinga, Turski Waldemar A, van der Ent Wietske, Mathai Benan J, Kirstein-Smardzewska Karolina J, Simonsen Anne, Esguerra Camila V

Abstract excerpt

The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene, among others, have been described in patients and rodents suffering from absence seizures and episodic ataxia type 2 with/without concomitant seizures. In this study, we aimed for the first time to assess phenotypic and behavioral alterations in larval zebrafish with partial cacna1aa...

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Identifiers

PMID: 31875924
DOI: 10.1007/s12035-019-01860-x
PMCID: PMC7118054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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