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Article

Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Jul 2003

Mathews Eleanor A, García Esperanza, Santi Celia M, Mullen Gregory P, Thacker Colin, Moerman Donald G, Snutch Terrance P

Abstract excerpt

The Caenorhabditis elegans unc-2 gene encodes a voltage-gated calcium channel alpha1 subunit structurally related to mammalian dihydropyridine-insensitive high-threshold channels. In the present paper we describe the characterization of seven alleles of unc-2. Using an unc-2 promoter-tagged green fluorescent protein construct, we show that unc-2 is primarily expressed in motor neurons, several subsets of sensory...

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PMID: 12878695
PMCID: PMC6740628

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