Article
TRPM7 is required within zebrafish sensory neurons for the activation of touch-evoked escape behaviors.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Aug 2011
Low Sean E, Amburgey Kimberly, Horstick Eric, Linsley Jeremy, Sprague Shawn M, Cui Wilson W, Zhou Weibin, Hirata Hiromi, Saint-Amant Louis, Hume Richard I, Kuwada John Y
Abstract excerpt
Mutations in the gene encoding TRPM7 (trpm7), a member of the Transient Receptor Potential (TRP) superfamily of cation channels that possesses an enzymatically active kinase at its C terminus, cause the touch-unresponsive zebrafish mutant touchdown. We identified and characterized a new allele of touchdown, as well as two previously reported alleles, and found that all three alleles harbor mutations that abolish...
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