SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3.

doi:10.1002/gcc.21961

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Article

SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3.

Genes, chromosomes & cancer - 1 Aug 2012

Nowak Daniel, Klaumuenzer Marion, Hanfstein Benjamin, Mossner Maximilian, Nolte Florian, Nowak Verena, Oblaender Julia, Hecht Anna, Hütter Gero, Ogawa Seishi, Kohlmann Alexander, Haferlach Claudia, Schlegelberger Brigitte, Braess Jan, Seifarth Wolfgang, Fabarius Alice, Erben Philipp, Saussele Susanne, Müller Martin C, Reiter Andreas, Buechner Thomas, Weiss Christel, Hofmann Wolf-Karsten, Lengfelder Eva

Abstract excerpt

To search for new copy number alterations (CNAs) in acute promyelocytic leukemia (APL), we analyzed DNA from leukemic blasts of 93 acute promyelocytic leukemia (APL) patients with Genome-Wide SNP 6.0 arrays (SNP-A). We identified 259 CNAs consisting of 170 heterozygous deletions, 82 amplifications, and 7 regions of copy number neutral loss of heterozygosity. One of the most common CNAs was a deletion on...

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PMID: 22488577
DOI: 10.1002/gcc.21961

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FLT3

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