Article
Impact of SNP array karyotyping on the diagnosis and the outcome of chronic myelomonocytic leukemia with low risk cytogenetic features or no metaphases.
American journal of hematology - 1 Feb 2016
Palomo Laura, Xicoy Blanca, Garcia Olga, Mallo Mar, Ademà Vera, Cabezón Marta, Arnan Montse, Pomares Helena, José Larrayoz María, José Calasanz María, Maciejewski Jaroslaw P, Huang Dayong, Shih Lee-Yung, Ogawa Seishi, Cervera Jose, Such Esperanza, Coll Rosa, Grau Javier, Solé Francesc, Zamora Lurdes
Abstract excerpt
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder with heterogeneous clinical, morphological and genetic characteristics. Clonal cytogenetic abnormalities are found in 20-30% of patients with CMML. Patients with low risk cytogenetic features (normal karyotype and isolated loss of Y chromosome) account for ∼80% of CMML patients and often fall into the low risk categories of CMML prognostic...
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