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Article

Single-nucleotide polymorphism array-based karyotyping of acute promyelocytic leukemia.

PloS one - 1 Jan 2014

Gómez-Seguí Inés, Sánchez-Izquierdo Dolors, Barragán Eva, Such Esperanza, Luna Irene, López-Pavía María, Ibáñez Mariam, Villamón Eva, Alonso Carmen, Martín Iván, Llop Marta, Dolz Sandra, Fuster Oscar, Montesinos Pau, Cañigral Carolina, Boluda Blanca, Salazar Claudia, Cervera Jose, Sanz Miguel A

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), but additional chromosomal abnormalities (ACA) and other rearrangements can contribute in the development of the whole leukemic phenotype. We hypothesized that some ACA not detected by conventional techniques may be informative of the onset of APL. We performed the high-resolution SNP array (SNP-A) 6.0 (Affymetrix) in 48 patients...

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Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Karyotyping

Share to Leukemia, Promyelocytic, Acute

Share to Loss of Heterozygosity

Share to Oncogene Proteins, Fusion

Share to Translocation, Genetic

Source

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Identifiers

PMID: 24959826
DOI: 10.1371/journal.pone.0100245
PMCID: PMC4069034

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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