Article
Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies.
Blood - 28 Apr 2011
Tiu Ramon V, Gondek Lukasz P, O'Keefe Christine L, Elson Paul, Huh Jungwon, Mohamedali Azim, Kulasekararaj Austin, Advani Anjali S, Paquette Ronald, List Alan F, Sekeres Mikkael A, McDevitt Michael A, Mufti Ghulam J, Maciejewski Jaroslaw P
Abstract excerpt
Single nucleotide polymorphism arrays (SNP-As) have emerged as an important tool in the identification of chromosomal defects undetected by metaphase cytogenetics (MC) in hematologic cancers, offering superior resolution of unbalanced chromosomal defects and acquired copy-neutral loss of heterozygosity. Myelodysplastic syndromes (MDSs) and related cancers share recurrent chromosomal defects and molecular lesions...
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