Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression.

Leukemia - 1 Jun 2010

Boultwood J, Perry J, Zaman R, Fernandez-Santamaria C, Littlewood T, Kusec R, Pellagatti A, Wang L, Clark R E, Wainscoat J S

Abstract excerpt

We have undertaken a genome-wide single nucleotide polymorphism (SNP) array analysis of 41 chronic myeloid leukemia (CML) patients. In total, 44 regions of uniparental disomy (UPD) >3 Mb were identified in 24 of 32 patients in chronic phase (CP), and 21 regions of UPD >3 Mb were identified in 13 of 21 patients in blast crisis (BC). Chromosome 8 had the highest frequency of UPD regions in both CP and BC samples....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blast Crisis
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Karyotyping

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Oligonucleotide Array Sequence Analysis

Share to Repressor Proteins

Share to Uniparental Disomy

Source

Identifiers

PMID: 20410925
DOI: 10.1038/leu.2010.65

Genes

ASXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression.PMID 20410925Read ↗

Use of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemia.Semantic proximity Read ↗

SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3.Semantic proximity Read ↗

Impact of SNP array karyotyping on the diagnosis and the outcome of chronic myelomonocytic leukemia with low risk cytogenetic features or no metaphases.Semantic proximity Read ↗

Single-nucleotide polymorphism array-based karyotyping of acute promyelocytic leukemia.Semantic proximity Read ↗

New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia.Semantic proximity Read ↗

Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis.Semantic proximity Read ↗

250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies.Semantic proximity Read ↗

From cryptic chromosomal lesions to pathologically relevant genes: integration of SNP-array with gene expression profiling in myelodysplastic syndrome with normal karyotype.Semantic proximity Read ↗

Application of SNP genotype arrays to determine somatic changes in cancer.Semantic proximity Read ↗

High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations.Semantic proximity Read ↗

Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.Semantic proximity Read ↗

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.