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Article

Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D).

Scientific reports - 7 Nov 2017

Gurney Mark E, Cogram Patricia, Deacon Robert M, Rex Christopher, Tranfaglia Michael

Abstract excerpt

Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent finding in patients and in the mouse and fly FXS models. We therefore explored if BPN14770, a prototypic phosphodiesterase-4D negative allosteric modulator (PDE4D-NAM) in early human clinical...

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Share to Behavior, Animal
Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Fragile X Mental Retardation Protein

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Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 29116166
DOI: 10.1038/s41598-017-15028-x
PMCID: PMC5677090

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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