Article
Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain.
Molecular pain - 23 Jun 2009
Tan Ene-choo, Lim Eileen C P, Teo Yik-ying, Lim Yvonne, Law Hai-yang, Sia Alex T
Abstract excerpt
BACKGROUND: Morphine consumption can vary widely between individuals even for identical surgical procedures. As mu-opioid receptor (OPRM1) is known to modulate pain perception and mediate the analgesic effects of opioid compounds in the central nervous system, we examined the influence of two OPRM polymorphisms on acute post-operative pain and morphine usage in women undergoing elective caesarean delivery....
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