Exome sequencing of gastric adenocarcinoma identifies recurrent  somatic mutations in cell adhesion and chromatin remodeling genes.

doi:10.1038/ng.2246

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Article

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.

Nature genetics - 1 May 2012

Zang Zhi Jiang, Cutcutache Ioana, Poon Song Ling, Zhang Shen Li, McPherson John R, Tao Jiong, Rajasegaran Vikneswari, Heng Hong Lee, Deng Niantao, Gan Anna, Lim Kiat Hon, Ong Choon Kiat, Huang DaChuan, Chin Sze Yung, Tan Iain Beehuat, Ng Cedric Chuan Young, Yu Willie, Wu Yingting, Lee Minghui, Wu Jeanie, Poh Dianne, Wan Wei Keat, Rha Sun Young, So Jimmy, Salto-Tellez Manuel, Yeoh Khay Guan, Wong Wai Keong, Zhu Yi-Jun, Futreal P Andrew, Pang Brendan, Ruan Yijun, Hillmer Axel M, Bertrand Denis, Nagarajan Niranjan, Rozen Steve, Teh Bin Tean, Tan Patrick

Abstract excerpt

Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas and their matched normal DNAs. Frequently mutated genes in the adenocarcinomas included TP53 (11/15 tumors), PIK3CA (3/15) and ARID1A (3/15). Cell adhesion was the most enriched biological pathway among the frequently mutated genes. A...

Topics

Adenocarcinoma
Case-Control Studies
Cell Adhesion
Chromatin Assembly and Disassembly
DNA
Exome
Gastric Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Tumor Suppressor

Humans

Microsatellite Instability

Mutation

Polymerase Chain Reaction

Polymorphism, Single Nucleotide

Sequence Analysis, DNA

Stomach Neoplasms

Source

Open in PubMed

Identifiers

PMID: 22484628
DOI: 10.1038/ng.2246

Genes

FAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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