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Article

Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine.

Journal of translational medicine - 25 Jul 2011

Holbrook Joanna D, Parker Joel S, Gallagher Kathleen T, Halsey Wendy S, Hughes Ashley M, Weigman Victor J, Lebowitz Peter F, Kumar Rakesh

Abstract excerpt

BACKGROUND: Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries. METHODS: Here, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to...

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DNA Copy Number Variations
DNA, Neoplasm
Epithelium
Molecular Targeted Therapy
Precision Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

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Identifiers

PMID: 21781349
DOI: 10.1186/1479-5876-9-119
PMCID: PMC3152520

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