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Article

Comprehensive mutation profiling of mucinous gastric carcinoma.

The Journal of pathology - 1 Oct 2016

Rokutan Hirofumi, Hosoda Fumie, Hama Natsuko, Nakamura Hiromi, Totoki Yasushi, Furukawa Eisaku, Arakawa Erika, Ohashi Shoko, Urushidate Tomoko, Satoh Hironori, Shimizu Hiroko, Igarashi Keiko, Yachida Shinichi, Katai Hitoshi, Taniguchi Hirokazu, Fukayama Masashi, Shibata Tatsuhiro

Abstract excerpt

Mucinous gastric carcinoma (MGC) is a unique subtype of gastric cancer with a poor survival outcome. Comprehensive molecular profiles and putative therapeutic targets of MGC remain undetermined. We subjected 16 tumour-normal tissue pairs to whole-exome sequencing (WES) and an expanded set of 52 tumour-normal tissue pairs to subsequent targeted sequencing. The latter focused on 114 genes identified by WES....

Topics

Adenocarcinoma, Mucinous
Aged
Aged, 80 and over
DNA Mutational Analysis
Female
Humans
Male
Middle Aged
Mutation
Stomach Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27313181
DOI: 10.1002/path.4761

Genes

MYH9
BCOR
BRCA1
BRCA2
ERBB3
MLH1
MTOR
RHOA

Provenance

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