Article
An updated review of gastric cancer in the next-generation sequencing era: insights from bench to bedside and vice versa.
World journal of gastroenterology - 14 Apr 2014
Yamamoto Hiroyuki, Watanabe Yoshiyuki, Maehata Tadateru, Morita Ryo, Yoshida Yoshihito, Oikawa Ritsuko, Ishigooka Shinya, Ozawa Shun-Ichiro, Matsuo Yasumasa, Hosoya Kosuke, Yamashita Masaki, Taniguchi Hiroaki, Nosho Katsuhiko, Suzuki Hiromu, Yasuda Hiroshi, Shinomura Yasuhisa, Itoh Fumio
Abstract excerpt
Gastric cancer (GC) is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide. There is an increasing understanding of the roles that genetic and epigenetic alterations play in GCs. Recent studies using next-generation sequencing (NGS) have revealed a number of potential cancer-driving genes in GC. Whole-exome sequencing of GC has identified recurrent somatic...
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