Article
Identification of somatic alterations in stage I lung adenocarcinomas by next-generation sequencing.
Genes, chromosomes & cancer - 1 Apr 2014
Zhao Yuda, Yang Jie, Chen Zhaoli, Gao Zhibo, Zhou Fang, Li Xiangchun, Li Jiagen, Shi Susheng, Feng Xiaoli, Sun Nan, Yao Ran, Zhou Chengcheng, Chang Sheng, Li Miao, Zhou Yong, Li Lin, Zhang Xiuqing, He Jie
Abstract excerpt
Adenocarcinoma is the most common type of lung cancer. Somatic mutations in the early stage of this disease have a tight relationship with tumor initiation and potentially activate downstream pathways that are implicated in tumor progression. In this study, we performed whole genome and exome sequencing of tumor and adjacent normal tissue from 10 patients with stage I lung adenocarcinoma. EGFR (4/10 tumors), BCHE...
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