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Article

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2018

Zhang Yuan-Wei, Tavoulari Sotiria, Sinning Steffen, Aleksandrova Antoniya A, Forrest Lucy R, Rudnick Gary

Abstract excerpt

The coupled transport of ions and substrates allows transporters to accumulate substrates using the energy of transmembrane ion gradients and electrical potentials. During transport, conformational changes that switch accessibility of substrate and ion binding sites from one side of the membrane to the other must be controlled so as to prevent uncoupled movement of ions or substrates. In the...

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Identifiers

PMID: 30181291
DOI: 10.1073/pnas.1716870115
PMCID: PMC6156673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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