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Article

Phenotypic and functional properties of Helios+ regulatory T cells.

PloS one - 1 Jan 2012

Zabransky Daniel J, Nirschl Christopher J, Durham Nicholas M, Park Ben V, Ceccato Christina M, Bruno Tullia C, Tam Ada J, Getnet Derese, Drake Charles G

Abstract excerpt

Helios, an Ikaros family transcription factor, is preferentially expressed at the mRNA and protein level in regulatory T cells. Helios expression previously appeared to be restricted to thymic-derived Treg. Consistent with recent data, we show here that Helios expression is inducible in vitro und...

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Identifiers

PMID: 22479644
DOI: 10.1371/journal.pone.0034547
PMCID: PMC3316700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22479644-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Phenotypic and functional properties of Helios+ regulatory T cells.PMID 22479644Read ↗

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Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.Semantic proximity Read ↗

Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice.Semantic proximity Read ↗

Helios characterized circulating follicular helper T cells with enhanced functional phenotypes and was increased in patients with systemic lupus erythematosus.Semantic proximity Read ↗

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