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Article

Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice.

Blood - 1 Mar 2007

Zhang Zheng, Swindle C Scott, Bates John T, Ko Rose, Cotta Claudiu V, Klug Christopher A

Abstract excerpt

Helios is a zinc-finger protein belonging to the Ikaros family of transcriptional regulators. It is expressed, along with Ikaros, throughout early stages of thymocyte development where it quantitatively associates with Ikaros through C-terminal zinc-finger domains that mediate heterodimerization...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Killer Cells, Natural

Share to Lymphoma, T-Cell

Share to Protein Isoforms

Share to Thymus Gland

Source

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Identifiers

PMID: 17110463
DOI: 10.1182/blood-2005-01-031930
PMCID: PMC1801072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17110463-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice.PMID 17110463Read ↗

Genetic mapping and allelic loss analysis in mouse thymic lymphomas of Helios and Aiolos belonging to the Ikaros gene family.Semantic proximity Read ↗

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory CellsSemantic proximity Read ↗

T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice.Semantic proximity Read ↗

Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.Semantic proximity Read ↗

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma.Semantic proximity Read ↗

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL.Semantic proximity Read ↗

Ikaros, Aiolos and Helios: Transcription regulators and lymphoid malignanciesSemantic proximity Read ↗

Phenotypic and functional properties of Helios+ regulatory T cells.Semantic proximity Read ↗

Ikaros is a principal regulator of Aire + mTEC homeostasis, thymic mimetic cell diversity, and central toleranceSemantic proximity Read ↗

Transcriptional regulation of the Ikzf1 locusSemantic proximity Read ↗

Loss-of-function mutation in <i>IKZF2</i> leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cellsSemantic proximity Read ↗

Helios is a marker, not a driver, of human Treg stabilitySemantic proximity Read ↗

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