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Article

Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells

7 Apr 2020

Abstract excerpt

Regulatory T cells (Tregs) are a subset of immune cells that suppress the immune response. Treg therapy for inflammatory diseases is being tested in the clinic, with moderate success. However, it is difficult to isolate and expand Tregs to sufficient numbers. Engineered Tregs (eTregs) can be generated in larger quantities by genetically manipulating conventional T cells to express FOXP3. These eTregs can suppress...

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PMID: 32259202
DOI: 10.1182/bloodadvances.2019000965

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