Article

Helios is a marker, not a driver, of human Treg stability

2021-04-28

Abstract excerpt

Regulatory T cell (Treg) therapy holds promise as a potentially curative approach to establish immune tolerance in transplantation and autoimmune disease. An outstanding question is whether therapeutic Tregs have the potential to transdifferentiate into effector T cells and thus exacerbate rather than suppress immune responses. In mice, the transcription factor Helios is thought to promote Tregs lineage stability...

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Literature Corpus work: f8a25974-ef22-5be9-b1ec-8a75064b2356
DOI: 10.1101/2021.04.27.441702

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