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Article

A universal code for RNA recognition by PUF proteins.

Nature chemical biology - 15 May 2011

Filipovska Aleksandra, Razif Muhammad F M, Nygård Karoline K A, Rackham Oliver

Abstract excerpt

The design of proteins that can bind any RNA sequence of interest has many potential biological and medical applications. Here we have expanded the recognition of Pumilio and FBF homology protein (PUF) repeats beyond adenine, guanine and uracil and evolved them to specifically bind cytosine. These repeat sequences can be used to create PUF domains capable of selectively binding RNA targets of diverse sequence and...

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Identifiers

PMID: 21572425
DOI: 10.1038/nchembio.577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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