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Article

Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.

Journal of oral science - 1 Mar 2012

Miyazaki Yuji, Inoue Harumi, Kikuchi Kentaro, Ochiai Kuniyasu, Kusama Kaoru

Abstract excerpt

Activation-induced cytidine deaminase (AID) induces cytosine deamination to generate somatic hypermutation and class switch recombnation in immunoglobulin genes. AID expression is upregulated by inflammatory cytokines such as interferon-γ and tumor necrosis factor (TNF)-α, which in turn induce p53 mutations in inflammatory or cancer cells. In this study, the effects of growth factors, cytokines or sodium butyrate...

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Source

Identifiers

PMID: 22466889
DOI: 10.2334/josnusd.54.71

Genes

TNF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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