Article
Growth factor-dependent differentiation along the myeloid and lymphoid lineages in an immature acute T lymphocytic leukemia.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1990
O'Connor R, Cesano A, Kreider B L, Lange B, Clark S C, Nowell P C, Finan J, Rovera G, Santoli D
Abstract excerpt
Bone marrow cells from a child with an immature (CD2+, CD5+, CD7+) acute T lymphocytic leukemia (T-ALL) were cultured in the presence and absence of human rIL-2, IL-3, or granulocyte-macrophage (GM)-CSF. Cells cultured without growth factors failed to divide and those initiated in the presence of...
Topics
- Antigens, CD
- Cell Differentiation
- Child
- Gene Rearrangement, T-Lymphocyte
- Genotype
- Granulocyte-Macrophage Colony-Stimulating Factor
- Growth Substances
- Humans
- Interleukin-2
- Interleukin-3
- Karyotyping
- Male
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Tumor Cells, Cultured