Article
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency.
Blood - 1 Dec 1995
Jeha S, Kantarjian H, O'Brien S, Huh Y, Pisa P, Ordonez N, Beran M
Abstract excerpt
Modest progress has been achieved over the past two decades in the treatment of adult acute lymphocytic leukemia (ALL). With modern therapy, response rates are 70% to 80%, but cure rates only average 25% to 30%. Improved in vivo models are needed to investigate the biology of adult ALL and to test new treatment concepts. Fresh leukemia samples from children with ALL have been successfully transplanted into mice...
Topics
- Adolescent
- Adult
- Aged
- Animals
- Cell Division
- Cyclophosphamide
- DNA, Neoplasm
- Disease Models, Animal
- Female
- Humans
- Immunohistochemistry