Article
Characterization of an interleukin-2 dependent human leukemic cell line, PER-315, with an immature T cell phenotype which does not express the tac antigen.
Leukemia - 1 Apr 1990
Kees U R, Ford J, Ranford P R, Dawson V M
Abstract excerpt
Cell line PER-315 was established from a bone marrow sample of a 5-year-old boy diagnosed with acute lymphoblastic leukemia (ALL) of T cell lineage. PER-315 cells express the surface markers present on immature thymocytes, express cytoplasmic CD3, and their growth is dependent on interleukin-2 (I...
Topics
- Antigens, Neoplasm
- Antigens, Surface
- Cell Line
- Child, Preschool
- Culture Media
- Cytotoxicity, Immunologic
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Humans
- Immunoglobulin J-Chains
- Interleukin-2
- Killer Cells, Lymphokine-Activated
- Leukemia, Experimental
- Leukemia, T-Cell
- Male
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Interleukin-2
- Recombinant Proteins