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Article

Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and express high levels of the transcriptional repressor Gfi-1.

Clinical & developmental immunology - 1 Jan 2013

Purizaca Jessica, Contreras-Quiroz Adriana, Dorantes-Acosta Elisa, Vadillo Eduardo, Arriaga-Pizano Lourdes, Fuentes-Figueroa Silvestre, Villagomez-Barragán Horacio, Flores-Guzmán Patricia, Alvarado-Moreno Antonio, Mayani Hector, Meza Isaura, Hernandez Rosaura, Huerta-Yepez Sara, Pelayo Rosana

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most frequent malignancy of childhood. Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has been recorded in the last few years, suggesting that both primitive cell fractions and committed lymphoid blasts with immature stem cell-like properties contain leukemia-initiating cells. Nevertheless, the biology of the early progenitors that...

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Identifiers

PMID: 24198842
DOI: 10.1155/2013/349067
PMCID: PMC3808104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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