Article
Growth factor requirements of childhood acute T-lymphoblastic leukemia: correlation between presence of chromosomal abnormalities and ability to grow permanently in vitro.
Blood - 1 Apr 1991
O'Connor R, Cesano A, Lange B, Finan J, Nowell P C, Clark S C, Raimondi S C, Rovera G, Santoli D
Abstract excerpt
Cells from 10 cases of childhood acute T-lymphoblastic leukemia (T-ALL) were cultured in the presence of recombinant human interleukins (rhIL) or colony-stimulating factors (CSF) to analyze their growth factor requirements and differentiative potential. Although cells from most leukemic samples displayed a short-term proliferative response to several hematopoietic growth factors, only the ones featuring...
Topics
- Adolescent
- Antigens, Neoplasm
- Antigens, Surface
- Cell Division
- Child
- Child, Preschool
- Chromosome Aberrations
- Chromosome Disorders
- Female
- Granulocyte Colony-Stimulating Factor